Lack of association of lipoprotein(a) levels with coronary calcium deposits in asymptomatic postmenopausal women
Identifieur interne : 000A95 ( Main/Exploration ); précédent : 000A94; suivant : 000A96Lack of association of lipoprotein(a) levels with coronary calcium deposits in asymptomatic postmenopausal women
Auteurs : Masami Nishino [États-Unis] ; Mary J. Malloy [États-Unis] ; Josefina Naya-Vigne [États-Unis] ; Julie Russell [États-Unis] ; John P. Kane [États-Unis] ; Rita F. Redberg [États-Unis]Source :
- Journal of the American College of Cardiology [ 0735-1097 ] ; 1999.
English descriptors
Abstract
OBJECTIVESThis study sought to determine the relationship of lipoprotein(a) (Lp(a)) and other cardiac risk factors to coronary atherosclerosis as measured by calcification of coronary arteries in asymptomatic postmenopausal women.BACKGROUNDLipoprotein(a) is considered a risk factor for coronary heart disease. Coronary calcium deposition is believed to be a useful noninvasive marker of coronary atherosclerosis in women. However, to our knowledge, there are no reports of the relationship of Lp(a) to coronary calcium in postmenopausal women.METHODSIn 178 asymptomatic postmenopausal women (64 ± 8 years), we measured Lp(a) and other cardiac risk factors: age, hypertension, diabetes, low-density lipoprotein cholesterol, smoking status, body mass index, physical activity level and duration of hormone replacement therapy. Electron-beam computed tomography was done to measure coronary calcium (calcium score). We analyzed the relationship between calcium score and cardiac risk factors using multivariate analysis.RESULTSAlthough calcium score correlated with traditional risk factors of age, diabetes, hypertension and smoking, it did not correlate with Lp(a) in the asymptomatic postmenopausal women. Similar multivariate analyses were done in the subjects age >60 years and in the subjects with significant coronary calcium deposit (calcium score ≥50). These analyses also have failed to show an association of levels of Lp(a) with coronary calcium deposits.CONCLUSIONSWe conclude that in asymptomatic postmenopausal women, Lp(a) levels do not correlate with coronary atherosclerosis as measured by coronary calcium deposits.
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DOI: 10.1016/S0735-1097(99)00555-0
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Kane</name></author><author><name sortKey="Redberg, Rita F" sort="Redberg, Rita F" uniqKey="Redberg R" first="Rita F" last="Redberg">Rita F. 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Malloy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Research Institute, University of California, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Naya Vigne, Josefina" sort="Naya Vigne, Josefina" uniqKey="Naya Vigne J" first="Josefina" last="Naya-Vigne">Josefina Naya-Vigne</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cardiovascular Research Institute, University of California, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Russell, Julie" sort="Russell, Julie" uniqKey="Russell J" first="Julie" last="Russell">Julie Russell</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiology, University of California, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kane, John P" sort="Kane, John P" uniqKey="Kane J" first="John P" last="Kane">John P. 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Redberg</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Cardiology, University of California, San Francisco, California</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the American College of Cardiology</title><title level="j" type="abbrev">JAC</title><idno type="ISSN">0735-1097</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">35</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="314">314</biblScope><biblScope unit="page" to="320">320</biblScope></imprint><idno type="ISSN">0735-1097</idno></series><idno type="istex">10B1C36C266EDFE64942E99EFF328D614A76790A</idno><idno type="DOI">10.1016/S0735-1097(99)00555-0</idno><idno type="PII">S0735-1097(99)00555-0</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0735-1097</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>CHD</term><term>EBCT</term><term>HDL</term><term>HU</term><term>LDL</term><term>Lp(a)</term><term>Mets</term><term>UCSF</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">OBJECTIVESThis study sought to determine the relationship of lipoprotein(a) (Lp(a)) and other cardiac risk factors to coronary atherosclerosis as measured by calcification of coronary arteries in asymptomatic postmenopausal women.BACKGROUNDLipoprotein(a) is considered a risk factor for coronary heart disease. Coronary calcium deposition is believed to be a useful noninvasive marker of coronary atherosclerosis in women. However, to our knowledge, there are no reports of the relationship of Lp(a) to coronary calcium in postmenopausal women.METHODSIn 178 asymptomatic postmenopausal women (64 ± 8 years), we measured Lp(a) and other cardiac risk factors: age, hypertension, diabetes, low-density lipoprotein cholesterol, smoking status, body mass index, physical activity level and duration of hormone replacement therapy. Electron-beam computed tomography was done to measure coronary calcium (calcium score). We analyzed the relationship between calcium score and cardiac risk factors using multivariate analysis.RESULTSAlthough calcium score correlated with traditional risk factors of age, diabetes, hypertension and smoking, it did not correlate with Lp(a) in the asymptomatic postmenopausal women. Similar multivariate analyses were done in the subjects age >60 years and in the subjects with significant coronary calcium deposit (calcium score ≥50). These analyses also have failed to show an association of levels of Lp(a) with coronary calcium deposits.CONCLUSIONSWe conclude that in asymptomatic postmenopausal women, Lp(a) levels do not correlate with coronary atherosclerosis as measured by coronary calcium deposits.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="États-Unis"><region name="Californie"><name sortKey="Nishino, Masami" sort="Nishino, Masami" uniqKey="Nishino M" first="Masami" last="Nishino">Masami Nishino</name></region><name sortKey="Kane, John P" sort="Kane, John P" uniqKey="Kane J" first="John P" last="Kane">John P. Kane</name><name sortKey="Malloy, Mary J" sort="Malloy, Mary J" uniqKey="Malloy M" first="Mary J" last="Malloy">Mary J. Malloy</name><name sortKey="Naya Vigne, Josefina" sort="Naya Vigne, Josefina" uniqKey="Naya Vigne J" first="Josefina" last="Naya-Vigne">Josefina Naya-Vigne</name><name sortKey="Redberg, Rita F" sort="Redberg, Rita F" uniqKey="Redberg R" first="Rita F" last="Redberg">Rita F. Redberg</name><name sortKey="Russell, Julie" sort="Russell, Julie" uniqKey="Russell J" first="Julie" last="Russell">Julie Russell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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